LTFHPlus - Implementation of LT-FH++
Implementation of LT-FH++, an extension of the liability
threshold family history (LT-FH) model. LT-FH++ uses a Gibbs
sampler for sampling from the truncated multivariate normal
distribution and allows for flexible family structures. LT-FH++
was first described in Pedersen, Emil M., et al. (2022)
<doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with
more flexible family structures, and again as the age-dependent
liability threshold (ADuLT) model Pedersen, Emil M., et al.
(2023) <https://www.nature.com/articles/s41467-023-41210-z> as
an alternative to traditional time-to-event genome-wide
association studies, where family history was not considered.
